Epigenetic / DNA-methylation biological age clock

Methylation clocks are well established as population-level correlates: they predict all-cause mortality and age-related disease risk better than chronological age in large prospective cohorts. That is association, not utility. The interventional evidence is thin and does not support the way the test is sold. The most-cited human trial is a pilot RCT in Aging (2021, n=43 healthy men aged 50-72, 8-week diet and lifestyle programme) reporting a 3.23-year reduction in DNAmAge versus controls; the authors themselves call for larger and longer trials, the cohort was narrow, and several investigators disclosed financial interests in the intervention. Critically, the outcome measured was the clock readout itself, not a healthspan or mortality outcome. As of this research there is no RCT showing that measuring a methylation clock, or acting on the number it produces, improves any hard health outcome. Practical limits compound this: clocks are not standardised between labs, test-retest variability can be on the order of years, results are not diagnostic, and there is no validated clinical protocol for what to change if the number comes back high. Reasonable use is as a research-grade engagement or tracking metric, explicitly labelled as such. It should not be presented as a clinically actionable measure of ageing.

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What is Epigenetic / DNA-methylation biological age clock?

Methylation clocks are well established as population-level correlates: they predict all-cause mortality and age-related disease risk better than chronological age in large prospective cohorts. That is association, not utility. The interventional evidence is thin and does not support the way the test is sold. The most-cited human trial is a pilot RCT in Aging (2021, n=43 healthy men aged 50-72, 8-week diet and lifestyle programme) reporting a 3.23-year reduction in DNAmAge versus controls; the authors themselves call for larger and longer trials, the cohort was narrow, and several investigators disclosed financial interests in the intervention. Critically, the outcome measured was the clock readout itself, not a healthspan or mortality outcome. As of this research there is no RCT showing that measuring a methylation clock, or acting on the number it produces, improves any hard health outcome. Practical limits compound this: clocks are not standardised between labs, test-retest variability can be on the order of years, results are not diagnostic, and there is no validated clinical protocol for what to change if the number comes back high. Reasonable use is as a research-grade engagement or tracking metric, explicitly labelled as such. It should not be presented as a clinically actionable measure of ageing.

How strong is the evidence for Epigenetic / DNA-methylation biological age clock?

Commercial. It is offered and sold, which is a statement about availability, not about efficacy.

Is Epigenetic / DNA-methylation biological age clock approved in Singapore?

Health Sciences Authority position on record: Not verified as an HSA-registered or HSA-classified product. Singapore's published framework distinguishes clinical genetic testing, which is a licensable healthcare service under the Healthcare Services Act and per MOH "can only be offered by doctors", from non-clinical genetic testing for personal wellbeing or recreational purposes, which does not require an HCSA licence and is not regulated under health products regulations. Methylation age clocks are marketed in Singapore as wellness or self-knowledge tests rather than diagnostic devices, which places them on the non-clinical side of that line, though no HSA determination specific to epigenetic age clocks was located. HBRA and PDPA obligations still apply. Treat this as framework-level context, not a product-specific regulatory clearance.. An evidence grade and a regulatory approval are different questions.

Is Epigenetic / DNA-methylation biological age clock approved in Australia?

variis has no Therapeutic Goods Administration position on file for Epigenetic / DNA-methylation biological age clock. Absence of a recorded position is not approval.

Which clinics offer Epigenetic / DNA-methylation biological age clock?

2 clinics in the variis directory across Singapore and Australia have Epigenetic / DNA-methylation biological age clock on record. Each is listed on this page with its own sourced profile.

What else is Epigenetic / DNA-methylation biological age clock called?

Also known as DNA methylation age, DNAmAge, epigenetic clock, biological age testing, LinAge 2.0, Horvath clock, OMICmAge, DunedinPACE, TruAge.